Nalbuphine

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A medicinal product belonging to the group of pain-relieving medicines (opioid analgesics). It is used for the short-term relief of moderate to severe pain. It is also highly suitable for the relief of labour pains. The medicine may also be used to treat pain following a caesarean section or other obstetric surgery. Nalbuphine does not affect the mother’s respiratory centre to the same extent as other commonly used opioid-based painkillers (e.g. Dolsin®). It has no adverse effect on the smooth muscles of the digestive and urinary tracts and therefore does not cause urinary retention or constipation. The onset of action depends on the route of administration. Analgesia following intravenous administration begins in approximately 3–15 minutes and lasts for 3–6 hours. The dose may be repeated after this period. As nalbuphine, unlike other opioids, does not release histamine, it does not cause skin itching. At the recommended dosage of nalbuphine (15–20 mg), no significant sedative effect on the infant has been demonstrated, even during breastfeeding. These properties make nalbuphine a highly suitable analgesic for pain relief in obstetrics.